Crystal structure of the cis-dimer of nectin-1 1 CRYSTAL STRUCTURE OF THE CIS–DIMER OF NECTIN-1: IMPLICATIONS FOR THE ARCHITECTURE OF CELL–CELL JUNCTIONS

1 CRYSTAL STRUCTURE OF THE CIS–DIMER OF NECTIN-1: IMPLICATIONS FOR THE ARCHITECTURE OF CELL–CELL JUNCTIONS Hirotaka Narita, Yasunori Yamamoto, Mamoru Suzuki, Naoyuki Miyazaki, Asuka Yoshida, Katsuhisa Kawai, Kenji Iwasaki, Atsushi Nakagawa, Yoshimi Takai , and Toshiaki Sakisaka* From the Laboratory of Supramolecular Crystallography, Research Center for Structural and Functional Proteomics, Institute for Protein Research, Osaka University, Suita 565-0871, Japan, Division of Membrane Dynamics, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan, Laboratory of Protein Synthesis and Expression, Research Center for Structural and Functional Proteomics, Institute for Protein Research, Osaka University, Suita 565-0871, Japan, Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan. These authors contributed equally to this work. Running title: Crystal structure of the cis-dimer of nectin-1 *Corresponding author: Toshiaki Sakisaka. Tel: +81-78-382-5727, Fax: +81-78-382-5419, E-mail: [email protected]